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Naproxen
12%
29/237
Colchicine
28/237
Allopurinol
19%
46/237
Indomethacin
10%
23/237
Probenecid
44%
104/237
Select Answer to see Preferred Response
Uricosuric drugs, such as probenecid, should be avoid in patients with high uric acid excretion (generally, > 800 mg/24hr is indicative of a uric acid overproducer) because this increases the risk of forming uric acid stones. Uricosuric medications should only be used in patients who underexcrete uric acid. These agents should not be used in patients with a history of kidney stones, unless the stones have been confirmed to NOT be uric acid stones. Patients taking uricosuric agents should be instructed to have high fluid intake to minimize the risk of uric acid precipitation and stone formation. Incorrect Answers: Answer 1: Naproxen, a nonsalicylate NSAID, will decrease the risk of future acute arthritic attacks; however, it will NOT alter serum uric acid levels or prevent the formation of tophi or nephrolithiasis. Answer 2: Colchicine will decrease the risk of future acute arthritic attacks; however, it will NOT alter serum uric acid levels or prevent the formation of tophi or nephrolithiasis. Answer 3: Allopurinol is useful in both uric acid underexcretors and overproducers. Answer 4: Indomethacin, a nonsalicylate NSAID, will decrease the risk of future acute arthritic attacks; however, it will NOT alter serum uric acid levels or prevent the formation of tophi or nephrolithiasis.
4.6
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