Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Dimercaprol
11%
33/294
N-acetylcysteine
7%
20/294
Ammonium chloride
5%
14/294
Flumazenil
15/294
Fomepizole
67%
196/294
Select Answer to see Preferred Response
The clinical presentation is consistent with ethylene glycol, aka antifreeze, ingestion and toxicity. Administration of fomepizole would be the most appropriate treatment. Ethylene glycol is a colorless, ordorless, sweet-tasting liquid Note, antifreeze, which is mainly composed of ethylene glycol, can be a number of colors. The toxicity of ethylene glycol is derived from the product of its hepatic oxidation - oxalic acid. Ethylene glycol is first degraded by alcohol dehydrogenase to glycoaldehyde then by aldehyde dehydrogenase to glycolic acid then finally to oxalic acid, the toxic metabolite. Oxalic acid binds to calcium and forms calcium oxalate crystals that damage the heart, brain, lungs and kidneys. Fomepizole is a competitive inhibitor of the first enzymatic step in this process, preventing the conversion of ethylene glycol into its toxic metabolites. Incorrect Answers: Answer 1: Dimercaprol is used to treat arsenic, lead, and mercury poisoning. Answer 2: N-acetylcysteine is used to treat acetaminophen overdose. Answer 3: Ammonium chloride is used to acidify the urine to treat amphetamine overdose. Answer 4: Flumazenil is used to treat a benzodiazepine overdose.
4.8
(24)
Please Login to add comment