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Phosphodiester bonds
4%
6/162
Glycosidic bonds
78%
127/162
Peptide bonds
7%
12/162
Cystine bonds
7/162
Hydrogen bonds
2%
3/162
Select Answer to see Preferred Response
Glycosidic bonds, hydrolyzed by alpha-glucosidase, will no longer be cleaved (hydrolyzed) once miglitol is taken due to inhibition of the enzyme. Miglitol is an alpha-glucosidase inhibitor that prevents the breakdown of disaccharides/polysaccharides into monomers by alpha-glucosidases located along the intestinal brush border. Alpha-glucosidases hydrolyze glycosidic bonds, releasing the monomers held in disaccharides/polysaccharides. Miglitol prevents these bonds from being hydrolyzed. This delays sugar hydrolysis, resulting in a delayed glucose absorption. This is advantageous for patients with type II diabetes mellitus as it decreases postprandial hyperglycemia, thereby reducing insulin demand. Common side effects of these inhibitors are upset stomach, diarrhea, and flatulence. Incorrect Answers: These bonds are not affected by the consumption of miglitol. Answer 1: Phosphodiester bonds are the bonds in DNA. Answer 3: Peptide bonds are the bonds in the primary structure of proteins. Answer 4: Cystine bonds are formed by two cysteine residues and are involved in the tertiary and quaternary structure of proteins. Answer 5: Hydrogen bonds are involved in many structures such as proteins, DNA binding, etc.
3.5
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