Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Figure A
9%
31/328
Figure B
13%
44/328
Figure C
12%
39/328
Figure D
52%
172/328
Figure E
Select Answer to see Preferred Response
This patient presents with leukocyte adhesion deficiency type 1 (LAD-1) in which neutrophilia is observed on peripheral blood smear (Figure D) due to the inability of neutrophils to exit the bloodstream. LAD-1 is an autosomal recessive immunodeficiency causing phagocytic dysfunction. It is caused by a defect in the LFA-1 integrin protein on phagocytes which prevents their adherence and migration out of blood vessels. It presents with recurrent bacterial infections, absent pus formation, poor wound healing, and delayed separation of the umbilical cord. Neutrophilia will be observed on the peripheral blood smear due to the inability of phagocytes to exit circulation. Figures are described in the incorrect answer choice explanations below. Incorrect Answers: Answer 1: Figure A demonstrates a normal peripheral blood smear. In LAD, the peripheral blood smear would demonstrate neutrophilia. Answer 2: Figure B demonstrates giant granules in neutrophils as is observed in Chediak-Higashi syndrome. Answer 3: Figure C demonstrates thrombocytopenia as is observed in Wiskott-Aldrich syndrome Answer 5: Figure E demonstrates a negative nitroblue tetrazolium (NBT) test which is observed in chronic granulomatous disease. Illustration A demonstrates a positive NBT.
4.8
(16)
Please Login to add comment