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Review Question - QID 106620

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QID 106620 (Type "106620" in App Search)
A codon is an mRNA sequence consisting of 3 nucleotides that codes for an amino acid. Each position can be made up of any 4 nucleotides (A, U, G, C); therefore, there are a total of 64 (4 x 4 x 4) different codons that can be created but they only code for 20 amino acids. This is explained by the wobble phenomenon. One codon for leucine is CUU, which of the following can be another codon coding for leucine?

AUG

1%

6/414

UAA

7%

28/414

CCC

1%

6/414

CCA

4%

15/414

CUA

85%

352/414

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Due to the wobble phenomenon, there are four codons that code for leucine: CUU, CUC, CUA, and CUG. It is not necessary to memorize codons for specific amino acids except for the start and stop codons but it is important to understand the wobble phenomenon (described below).

The wobble phenomenon describes how 64 different codons can code for only 20 amino acids. The first 2 nucleotide positions provide specificity for an individual amino acid whereas there the third position allows for flexibility as the Watson-Crick base pairing is not as strong as the first two. For example, leucine is specified by the first two nucleotides in the codon being CU and the third can be any of the four nucleotides A, C, U, or G (leucine codons: CUU, CUC, CUA, and CUG). Thus, the genetic code is degenerate as all the amino acids except for one have more than one codon.

Incorrect Answers:
Answer 1-4: There are a few codons one should know - AUG, UAA, UGA, and UAG. AUG is the start codon and represents methionine. UAA, UGA, and UAG are all stop codons and do not specify for an amino acid. CCC and CCA are codons that code for proline and do not need to be memorized, but it is important to understand that the wobble phenomenon allows for flexibility only in the third codon.

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