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Review Question - QID 106594

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QID 106594 (Type "106594" in App Search)
A 32-year-old man with a history of alcohol binge drinking and polysubstance use is found down in his hotel room with bottles of alcohol, oxycodone, alprazolam, amphetamine-dextroamphetamine, and tadalafil. When EMS arrives, he appears comatose with pinpoint pupils and oxygen saturation of 80% on room air. He is intubated at the scene and airlifted to the nearest intensive care unit. Body temperature is 95 degrees F (35 degrees C). Creatine phosphokinase is 12,000 U/L. MRI of the brain demonstrates extensive infarcts consistent with acute hypoxic ischemic injury. Which of the following is the likely culprit for his overdose?