Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Figure A
21%
81/391
Figure B
51%
199/391
Figure C
10%
39/391
Figure D
9%
37/391
Figure E
4%
15/391
Select Answer to see Preferred Response
Phenylketonuria (PKU) is an autosomal recessive disease due to a decrease in phenylalanine hydroxylase that occurs in approximately 1 in 10,000 people. Autosomal recessive diseases follow an inheritance pattern as shown in Figure B. There are several modes of inheritance, with the most common being autosomal dominant, autosomal recessive, X-linked recessive, X-linked dominant, and mitochondrial inheritance. Autosomal recessive modes of inheritance affects males and females equally. The disease is silent in heterozygotes, but 1/4 of the children of carrier parents will be homozygous and affected by the disease. Examples of autosomal recessive diseases include cystic fibrosis, inborn errors of metabolism (e.g. PKU), sickle cell anemia, and hemochromatosis. Figures explained in the Incorrect Answers section. Incorrect Answers: Answer 1: Figure A demonstrates the X-linked recessive mode of inheritance. Note that 50% of sons from the carrier mothers are affected. There is no male-to-male transmission. Answer 3: Figure C demonstrates the X-linked dominant mode of inheritance. Note that all the daughters of the affected fathers have the disease. Answer 4: Figure D demonstrates the autosomal dominant mode of inheritance. Note that every generation is affected. Answer 5: Figure E demonstrates the mitochondrial inheritance pattern. Note that all the children of the affected mother have the disease.
3.3
(10)
Please Login to add comment