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Review Question - QID 106341

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QID 106341 (Type "106341" in App Search)
An 18-year-old male in his first year of college presents to the emergency room with a fever and a severe headache. He reports having unprotected sex with several partners over the past few weeks. Upon examination, the male demonstrates nuchal rigidity and photophobia. His past medical history is notable for a lack of vaccinations beginning from infancy due to his parents' belief that vaccinations may cause autism. The bacteria causing these symptoms would most likely demonstrate which of the following?

Positive quellung reaction

55%

157/284

Negative quellung reaction

5%

13/284

Lactose fermentation

7%

21/284

Urease positive

5%

14/284

Negative catalase test

23%

64/284

Select Answer to see Preferred Response

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Due to the lack of vaccinations, living in close quarters such as the college dormitory, and the symptoms of fever, severe headache, nuchal rigidity, and photophobia, this male is most likely experiencing meningitis caused by Neisseria meningitidis. N. meningitidis would demonstrate a positive quellung reaction because it contains a capsule.

N. meningitidis is a maltose-fermenting, catalase positive, gram-negative cocci that is transmitted via oral and respiratory secretions. The difference between N. gonorrhea and N. meningitidis is the presence of a polysaccharide capsule which would produce a positive quellung reaction when anticapsular antisera is added. The capsule is also used to classify strains into serogroups. High risk groups typically include those who live in close quarters such as college students in dormitories, the military, and infants 6 months to 2 years since maternal antibodies only confer protection during the first 6 months of life.

Kimmel reviews the prevention of meningitis via the meningococcal vaccine which contains the most common serotypes (A, C, Y, and W-135) that cause over 70 to 80 percent of infections. For those individuals who are in close contact with an infected individual, it is recommended that they receive antibiotic chemoprophylaxis with rifampin, ciprofloxacin, or ceftriaxone.

Keiser et al. discuss three case reports of meningitis in the military all resulting in fatalities. Although every member of the military receives the quadrivalent meningitis vaccine, the rate of meningococcal disease is roughly similar or greater than the civilian population. Individuals from all parts of the US are brought together during training and undergo extreme training which is believe to further predispose them to the disease. Although the vaccine is given, it is still necessary to remain vigilant when living in close quarters and suspecting symptoms begin to present in an individual.

Illustration A contrasts a negative and a positive quellung reaction.

Incorrect Answers:
Answer 2-5: These are not characteristics of N. meningitidis.

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