Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Imatinib
16%
26/165
Indomethacin
2%
4/165
Cyclophosphamide
4%
6/165
Trastuzumab
73%
121/165
Allopurinol
1%
1/165
Select Answer to see Preferred Response
Infliximab is a monoclonal antibody targeting tumor necrosis factor alpha (TNF-alpha). Of the answer choices, only trastuzumab (Herceptin) is a monoclonal antibody. It targets the HER2/neu receptor in HER2 positive breast cancer. Infliximab is a chimeric monoclonal antibody. Common indications for usage include rheumatoid arthritis, Crohn's disease, ankylosing spondylitis, ulcerative colitis, and psoriatic arthritis. Because infliximab can have dangerous immunosuppressive toxicity, it is generally a second-line treatment for diseases refractory to more benign first-line treatments. In rheumatoid arthritis, anti-TNF-alpha agents are used when NSAIDs and first-line disease modifying drugs like methotrexate fail to control symptoms or disease progression. Adams and Bornemann review the use of infliximab in inflammatory bowel disease. Infliximab can be used in active ulcerative colitis refractory to corticosteroids. If successful in active disease treatment, it can be used as maintenance therapy following remission. Tanaka reviews anti-TNF-alpha therapy in rheumatoid arthritis. The success of TNF-alpha inhibitors in generating sustained disease remission has led to curiosity as to whether these agents must be used indefinitely as maintenance therapy. The author writes that studies suggest that 'treatment holidays' may be a possibility for patients with low disease activity and clinical remission, reducing side effects and healthcare expenditure. Illustration A models the antibody structure of infliximab. Incorrect Answers: Answer 1: Imatinib is a small molecule inhibitor of the BCR-ABL tyrosine kinase active in chronic myelogenous leukemia. Answer 2: Indomethacin, a NSAID, is a nonselective inhibitor of cyclooxygenase (COX) 1 and 2, enzymes that participate in prostaglandin synthesis from arachidonic acid. Answer 3: Cyclophosphamide is a nitrogen mustard alkylating agent used as a chemotherapeutic agent and an immunomodulator in the treatment of several cancers and inflammatory conditions, respectively. Answer 5: Allopurinol inhibits the enzyme xanthine oxidase. It is used to treat tumor lysis syndrome and gout.
2.6
(14)
Please Login to add comment