Review Question - QID 101512

Epstein-Barr virus or EBV reactivation is common in HIV+ and other immunosuppressed patients. EBV infection of B-cells can result in non-Hodgkins lymphomas such as Burkitt's lymphoma and diffuse large B cell lymphoma.

Non-Hodgkins lymphomas (NHL) comprise 60% of all lymphomas. Most are B-cell lymphomas (rather than T-cell), and one-third arise from outside of lymph nodes (e.g. from MALT). Approximately two-thirds of patients survive 5 years. Types of B-cell NHL include follicular (most common), Burkitt's, diffuse large B-cell, extranodal marginal zone, small lymphocytic, and mantle cell (rarest).

Incorrect answers:
Answer 1: HIV+ patients are at increased risk of P. jiroveci pneumonia (PCP) but this infection is not associated with an increased risk of malignancy.
Answer 2: HHV-6 causes roseola in infants. HHV-8 is the cause of Kaposi's sarcoma, a malignancy commonly seen in HIV+ patients.
Answer 3: Actinomyces israelii causes eroding abscesses of the mouth or GI tract. It is not associated with malignancies in HIV.
Answer 4: H. pylori infection is associated with an increased risk of gastric adenocarcinoma and MALToma, but this risk is not known to be affected by HIV status.