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Acetaldehyde
78%
423/545
Uric acid
2%
10/545
Cytochrome P-450 enzymes
16%
85/545
Triglycerides
1%
4/545
Amylase
3%
15/545
Select Answer to see Preferred Response
Metronidazole is commonly used to treat vaginitis caused by bacterial vaginosis or trichomonas. Metronidazole interferes with acetaldehyde metabolism, causing acetaldehyde to accumulate with concomitant alcohol consumption. Metronidazole has bactericidal and antiprotozoal effects. The drug is selectively absorbed by anaerobic bacteria and sensitive protozoa and forms metabolites toxic to DNA synthesis. Similar to disulfiram, metronidazole is thought to inhibit aldehyde dehydrogenase in alcohol metabolism and thus leads to an accumulation of acetaldehyde in patients that consume alcohol, producing symptoms such as flushing of the skin, headache, and others seen in this patient. Incorrect Answers: Answer 2: Pyrazinamide is used clinically to treat tuberculosis and may result in hyperuricemia. Answer 3: Several antimicrobials induce cytochrome P-450 enzymes. Examples include rimfampin (used for tuberculosis) and griseofulvin (used for oral treatment of superficial fungal infections). Answers 4-5: Metronidazole is not known to increase serum triglyceride or amylase levels.
4.4
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