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Barrett's esophagus
7%
16/218
H. pylori infection
10%
22/218
Adenomatous polyp
15%
33/218
Gastric ulcer
15/218
Duodenal ulcer
60%
131/218
Select Answer to see Preferred Response
In contrast to gastric ulcers, duodenal ulcers are not associated with the development of carcinoma. Ulcers are breaches in the wall of the gut that penetrate into and/or the submucosa. Both gastric and duodenal ulcers are often caused by H. pylori infection, and H. pylori is known to increase a patient's risk of developing gastric cancer. However, for reasons that are not well understood, duodenal ulcers do not result in the development of duodenal carcinoma. Adenocarcinoma of the small intestine is extremely rare, although it can occur sporadically. Ramakrishnan et al. reviews peptic ulcer disease (PUD). PUD is commonly seen in the stomach and proximal duodenum. NSAIDS and H. pylori are the predominant causes in the U.S. Patients complain of epigastric pain that may be either relieved by eating or antacids, loss of appetite and weight loss Biecker et al. discuss causes and treatment of gastrointestinal bleeding. PUD, angiodysplasias, Mallory-Weiss lesions and variceal disease are common causes of upper GI bleeding. Endoscopy allows diagnosis and therapeutic intervention. Illustration A shows immunohistochemical staining of H. pylori from a gastric biopsy. Incorrect answers: Answer 1: Barrett's esophagus is metaplasia of the esophagus that frequently progresses to adenocarcinoma. Answer 2: H. pylori infection is a common cause of gastric ulcers and raises a patient's risk of gastric carcinoma. Answer 3: Adenomatous colon polyps are precursors of colorectal cancer. Answer 4: Gastric ulcers are commonly caused by H. pylori, which raises a patient's risk of gastric carcinoma.
3.7
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