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Quinidine and insulin
4%
21/467
Encainide and epinephrine
7%
32/467
Propafenone and glucose
3%
16/467
Metoprolol and glucagon
63%
294/467
Sotalol and norepinephrine
19%
91/467
Select Answer to see Preferred Response
Metoprolol, like other beta-blockers, is treated with glucagon in overdose. Metoprolol, like other beta-blockers, is a class II antiarrhythmic that functions by decreasing automaticity. Glucagon acts independently of adrenoreceptors, enabling an inotropic and chronotropic response to compensate for the effects of beta-blocker overdose. Incorrect Answers: Answer 1: Quinidine is a class IA antiarrhythmic. Norepinephrine or metaraminol may be used to treat vascular collapse in the event of overdose. Answer 2: Encainide is a class IC antiarrhythmic. Attempts to treat toxicity with hypertonic sodium bicarbonate or molar lactate have been attempted in animals and humans with mixed success. Answer 3: Propafenone is a class IC antiarrhythmic. There is no well-established pharmacologic treatment of overdose. Answer 5: Sotalol is a class III antiarrhythmic, also with beta-blocker properties. Overdose could be treated with glucagon and supportive measures.
4.4
(13)
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