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Large arteries
5%
20/374
Large veins
71%
264/374
Arterioles
19%
72/374
Cardiac muscle
3%
13/374
Pulmonary arteries
1%
2/374
Select Answer to see Preferred Response
Drug X is nitroglycerin, which has low oral bioavailability and is therefore commonly administered sublingually to avoid the first-pass effect. Nitroglycerin acts as a venodilator. Nitrate drugs cause direct relaxation of arterial and venous smooth muscle. However, venodilation is primary effect at therapeutic doses. Venodilation causes blood to collect in the veins, thereby decreasing venous return to the heart. Decreased venous return decreases preload, lowering the oxygen demand of the myocardium and relieving the ischemia that causes angina. A second mechanism of action for nitroglycerin is via direct vasodilation on the coronary vasculature and collateral blood vessels to increase myocardial oxygen supply. Incorrect Answers: Answers 1, 3-5: As described above, the primary action of nitroglycerin is on veins.
4.4
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