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B cell class switching
81%
407/501
Stimulates IgA production
6%
30/501
Macrophage and Th1 cell activation
5%
27/501
Neutrophil chemotaxis
4%
22/501
Growth of cytotoxic T cells
1%
5/501
Select Answer to see Preferred Response
Interleukin (IL)-4 promotes class-switching of B cells from IgM to IgE and IgG. It is an important mediator of Type I hypersensitivity reactions following initial antigen exposure. Anaphylaxis occurs quickly in severe Type I hypersensitivity reactions. Free antigen cross-links pre-formed IgE on mast cells and basophils, prompting the release of the vasoactive substances histamine, heparin, and eosinophil chemotactic factor A. Symptoms of anaphylaxis include systemic vasodilation, bronchial/tracheal constriction, and others. Incorrect Answers: Answer 2: IL-5 is also responsible for B-cell class switching, but stimulates IgA production. Answer 3: Interferon-gamma activates macrophages and Th1 cells. Answer 4: IL-8 stimulates neutrophil chemotaxis. Answer 5: IL-2 promotes the growth of cytotoxic T cells .
4.4
(8)
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