Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Inhibiting thyroid peroxidase
16%
27/170
Inhibiting 5'-deiodinase
15%
26/170
Inhibiting thyroid deiodinase
5%
9/170
Inhibiting beta-adrenergic receptors
4%
7/170
Inhibiting iodide follicular uptake
51%
87/170
Select Answer to see Preferred Response
Thiocyanate and perchlorate both act to inhibit the Na-I symporter located on the basolateral membrane of thyroid epithelial cells. By decreasing iodide uptake, these drugs act to decrease the amount of thyroid hormone synthesized. Following the uptake of iodide, iodide and thyroglobulin are secreted into the follicular lumen. In the lumen, thyroid peroxidase-mediated reactions lead to the formation of thyroid hormones attached to thyroglobulin. Following TSH stimulation, this complex is brought back into the cell, thyroid hormones are cleaved from thyroglobulin, and the hormones are secreted into circulation. Illustration A depicts thyroid hormone synthesis. Note the Na-I sympoter on the basolateral surface; it is there where thiocyanate acts and inhibits the symporter. Incorrect Answers: Answer 1: PTU is a drug that inhibits thyroid peroxidase. Answer 2: Thiocyanate does not act on 5'-deiodinase. Answer 3: Thiocyanate does not act on thyroid deiodinase. The function of thyroid deiodinase is the release of T4/T3 from thyroglobulin. Answer 4: Propanolol is a drug that inhibits beta-adrenergic receptors.
4.5
(15)
Please Login to add comment