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Somatotroph
4%
15/345
Lactotroph
76%
262/345
Corticotroph
3%
12/345
Thyrotroph
2%
8/345
Gonadotroph
13%
46/345
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The patient is most likely suffering from a prolactinoma (lactotroph adenoma). Typical symptoms of this adenoma include amenhorrhea (in females), low libido, galactorrhea, and infertility. Prolactinomas can lead to the increased production of prolactin (hyperprolactinemia). In females, lactotroph adenomas are often recognized earlier due to the disruption of the menstrual cycle that hyperprolactinemia causes. In males, the symptoms are less profound, therefore they are not typically detected until their size causes optic nerve compression (leading to vision problems) and increased pressure in the cranial cavity (headache). Illustration A depicts the proximity of the pituitary gland to the optic chiasm. Large adenomas of the pituitary gland can compress the optic chiasm leading to characteristic vision defects. Incorrect Answers: Answer 1: Somatotrophs produce growth hormone. Answer 3: Corticotrophs produce ACTH (among other factors). Answer 4: Thyrotrophs produce TSH. Answer 5: Gonadotrophs produce FSH and LH.
3.4
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