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Review Question - QID 100069

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QID 100069 (Type "100069" in App Search)
In translation, the wobble phenomenon is best illustrated by the fact that:

A tRNA with the UUU anticodon can bind to either AAA or AAG codons

66%

340/512

There are more amino acids than possible codons

10%

49/512

The last nucleotide provides specificity for the given amino acid

14%

71/512

The genetic code is preserved without mutations

6%

30/512

Charged tRNA contains energy needed for peptide bonds to form

2%

10/512

Select Answer to see Preferred Response

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The wobble phenomenon refers to the ability of some tRNA molecules to bind to multiple codons.

There are more codons (61) than amino acids (20), so for each amino acid there are multiple possible codons. For example, lysine can be encoded by AAA or AAG. A single t-RNA molecule must then be able to bind to both codons - thus the bonds at the first and second positions are tighter than the third position. This is known as the wobble hypothesis. This also suggests that a mutation in the third position would be silent as it does not lead to a change in the amino acid sequence.

Incorrect Answers:
Answer 2: The opposite is true; there are more possible codons than amino acids.
Answer 3: The last nucleotide in the codon provides the least specificity in determining the amino acid.
Answer 4: The genetic code is copied with high but not complete fidelity.
Answer 5: This does not describe the wobble phenomenon.

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