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It binds the 50S ribosomal subunit and inhibits peptidyltransferase
5%
30/608
It binds the 50S ribosomal subunit and inhibits formation of the initiation complex
14%
87/608
It binds the 30s ribosomal subunit and inhibits formation of the initiation complex
62%
376/608
It binds the 30s ribosomal subunit and reversibly inhibits translocation
13%
77/608
It binds the 50s ribosomal subunit and reversibly inhibits translocation
4%
27/608
Select Answer to see Preferred Response
Neonatal meningitis due to Listeria or Group B Strep is commonly treated with ampicillin and gentamicin, an aminoglycoside antibiotic which carries a risk of ototoxicity. All aminoglycoside antibiotics bind to the prokaryocyte 30S ribosomal subunit in order to prevent initiation of protein synthesis. Gentamicin is among the most widely used aminoglycoside and is frequently employed against nosocomial infections. Other examples of aminoglycosies include streptomycin, neomycin, and amikacin. Because aminoglycosides inhibit formation of the initiation complex, they disrupt translation of prokaryotic mRNA, which causes bacterial cell death (bactericidal). Ototoxicity is a potential side effect and administration of gentamicin to pregnant women has even resulted in cases of fetal ototoxicity. Incorrect Answers: Answer 1, 2, 5: Aminoglycosides bind to the 30s subunit, not the 50S. Macrolide antibiotics, such as azithromycin, bind to the 50S subunit. Answer 4: Aminoglycosides, such as gentamicin bind irreversibly to the 30S subunit. Doxycycline is an example of an antibiotic which binds reversibly to the 30S subunit.
4.1
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