Review Question - QID 213521

A 75-year-old man presents to his physician after his daughter was concerned that his toe nails have become discolored. On physical examination, the nail plate of the great toe on both of his feet are yellow-brown, thickened, and appear both fragile and cracked (Figure A). A fungal culture is obtained and confirms a dermatophyte infection. The patient is prescribed a topical medication that inhibits the fungal enzyme squalene epoxidase. Which of the following is a potential adverse effect of this medication?