Leukocyte adhesion deficiency (LAD) is a defect of cellular adhesion molecules resulting in clinical syndromes. It is a combined (B cell) and cellular (T cell) immunodeficiency disorder. Major immunologic features[1][2]: There is an inability to form pus. There is a deficiency of various glycoproteins including LFA-1/Mac-1, glycoprotein 150/95. Leukocytes cannot migrate to infection sites to kill invading microorganisms due to mutations in the CD18 glycoprotein. Adhesion molecules deficiency results in an abnormal inflammatory response and eventually recurrent bacterial infections.