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Sulfasalazine
  • Mechanism 
    • sulfapyridine + 5-aminosalicylic acid
      • sulfapyridine is an antibiotic that surpresses B-cell function
      • 5-ASA is a COX inhibitor
    • joined molecule is split by colonic bacteria
  • Clinical use
    • ulcerative colitis
    • Crohn's disease
  • Toxicity
    • malaise/nausea
    • sulfa toxicity 
    • reversible oligospermia
    • hemolysis in G6PD deficiency
 

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