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Updated: Dec 29 2015

Carbohydrate Digestion

  • Overview
    • Overview
      • dietary carbohydrates include polysaccharides, disaccharides, and monosaccharides
        • intestinal epithelial cells absorb only monosaccharides
          • glucose, galactose, and fructose
    • Digestion of dietary polysaccharides
      • salivary secretions
        • salivary α-amylase initiates digestion of polysaccharides in mouth
          • digests interior α-1,4 glycosidic linkages, yielding 3 disaccharides
            • α-limit dextrins, maltose, and maltotriose
        • salivary α-amylase plays a minimal role in digestion of carbohydrates
          • low pH of gastric contents quickly inactivates salivary α-amylase
      • pancreatic secretions
        • pancreatic juices are secreted into lumen of duodenum of small intestine
        • pancreatic α-amylase initiates digestion of polysaccharides in the small intestines
          • digests interior α-1,4 glycosidic linkages, yielding 3 disaccharides
            • α-limit dextrins, maltose, and maltotriose
      • intestinal mucosa
        • intestinal brush border enzymes initiate digestion of disaccharides to monosaccharides
          • α-dextrinase catalyzes α-limit dextrins → glucose
          • maltase catalyzes maltose → glucose
          • sucrase catalyzes maltotriose → glucose
        • intestinal epithelial cells absorb glucose, a monosaccharide
    • Digestion of dietary disaccharides
      • dietary disaccharides include trehalose, lactose, and sucrose
      • dietary disaccharides do not require α-amylase digestion
      • intestinal brush border enzymes initiate digestion of disaccharides to monosaccharides
        • trehalase catalyzes trehalose → glucose + glucose
        • lactase catalyzes lactose → glucose + galactose
        • sucrase catalyzes sucrose → glucose + fructose
      • intestinal epithelial cells absorb glucose, galactose, and fructose, all monosaccharides
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