• Pancreatic secretions
    • overview
      • exocrine pancreas releases secretions into duodenum of small intestine
        • secretions contain aqueous and enzymatic components
          • aqueous component
            • contains HCO3-
              • neutralizes H+ delivered to duodenum from stomach
          • enzymatic component
            • contains pancreatic enzymes
              • digest carbohydrates, proteins, and lipids into absorbable molecules
              • lipid digestion begins in the duodenum; however, lipid absoprtion occurs primarily in the jejunum 
    • formation of pancreatic secretions
      • exocrine pancreas organization resembles that of salivary glands
      • acinar cells secrete enzymatic components of pancreatic secretions
        • see Pancreatic Enzymes
      • centroacinar cells and ductal cells secrete initial isotonic aqueous components of pancreatic secretions
      • ductal cells modify initial isotonic aqueous components by transport processes in ductal epithelial cells
        • modification results in HCO3- release into pancreatic secretions and net absorption of H+
          • causes acidification of pancreatic blood
        • pancreatic secretions remain isotonic
    • flow rate and composition of pancreatic secretions
      • flow rate changes HCO3- and Cl- concentrations in pancreatic secretions
        • reciprocal relationship
        • at highest flow rates
          • high HCO3- and low Cl-
        • at lowest flow rates
          • low HCO3- and high Cl-

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