Updated: 5/2/2019

Waldenstrom Macroglobulinemia

Topic
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Introduction
  • B cell lymphoma with monoclonal IgM production
Presentation
  • Symptoms 
    • generalized lymphadenopathy
    • bleeding
      • IgM disrupts platelet aggregation
    • sequelae of blood hyperviscosity
      • retinal hemorrhage
      • stroke
Evaluation
  • Serum protein electrophoresis 
    • M spike = IgM 
      • unlike multiple myeloma which is IgA/G
  • Urine
    • Bence Jones proteins will be present
      • Ig light chains
    • urine dipstick will be negative for protein as it detects only albumin
  • Imaging
    • no lytic bone lesions
Evaluation
  • Plasmapheresis
    • for acute episodes
 

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