Updated: 4/16/2018

Waldenstrom Macroglobulinemia

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Introduction
  • B cell lymphoma with monoclonal IgM production
Presentation
  • Symptoms 
    • generalized lymphadenopathy
    • bleeding
      • IgM disrupts platelet aggregation
    • sequelae of blood hyperviscosity
      • retinal hemorrhage
      • stroke
Evaluation
  • Serum protein electrophoresis 
    • M spike = IgM 
      • unlike multiple myeloma which is IgA/G
  • Imaging
    • no lytic bone lesions
Evaluation
  • Plasmapheresis
    • for acute episodes
 

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