Updated: 3/6/2018

Hodgkin vs. Non-Hodgkin Lymphoma

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Overview
  • There are many key differences between Hodgkin's and Non-Hodgkin's lymphoma
    • see individual topics
      • Hodgkin lymphoma
      • non-Hodgkin lymphoma
Characteristics  Hodgkin Non-Hodgkin
  • Cells involved
  • Reed-Sternberg Cells
  • B or T cells
  • Mass composition
  • Localized, single group of nodes
  • Extranodal spread is rare
  • Peripheral, multiple nodes
  • Often extranodal
  • Pattern of spread
  • Contiguous spread
  • Non-contiguous spread
  • Symptoms
  • Commonly with B symptoms, low-grade fever, night sweats, weight loss
  • Fewer constitutional symptoms
  • Leukemic phase
  • No
  • Yes
  • Associations
  • Associated with EBV (50%)
  • Seen more often with HIV/immunosuppression
  • Epidemiology - age distribution
  • Bimodal distribution (young adults and 50s-60s)
  • Peak incidence 20-40 years
  • Epidemiology - sex preference
  • More common in men
  • No difference
 

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