Updated: 3/15/2015

Foscarnet

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Introduction
  • Classification
    • antiviral
      • viral DNA polymerase inhibitors
        • foscarnet
  • Drugs
    • foscarnet
Mechanism
  • Action
    • pyrophosphate analog
      • "Foscarnet is a pyroFosphate analog"
    • binds to pyrophosphate site of DNA polymerase, directly inhibiting it
    • unlike acyclovir and ganciclovir, does not require activation by a viral kinase
    • also directly inhibits HIV reverse transcriptase
  • Resistance
    • via mutated DNA polymerase
Uses
  • CMV
    • when ganciclovir-resistant
  • HSV
    • when acyclovir-resistant
Adverse effects
  • Nephrotoxicity
    • with acute tubular necrosis
    • calcium chelation → hypocalcemia and hypomagnesemia
 

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