Topic
Review Topic
0
0
Snapshot
  • A 45-year-old man presents to his primary care physician for discoloration of his toenails. He reports that he has had this issue for the past few months. He denies any itching or pain associated with this toenail. On physical exam, his right big toenail is thickened with yellow discoloration. There are scale and fissures affecting the surrounding skin. Skin scrapings of the active edge mixed with potassium hydroxide reveal septated hyphae and spores. He is prescribed an oral medication that is particularly effective as it deposits in the nails (onychomycosis).  
Introduction
  • Drugs
    • griseofulvin
  • Mechanism of action
    • fungistatic
    • binds to microtubules and disrupts mitosis in fungi 
    • the drug deposits in tissue containing keratin (nails) and is thus particularly effective in dermatophytic infections
  • Clinical use
    • onychomycosis
    • dermatophytic infections
  • Adverse effects
    • photosensitivity
    • gastrointestinal upset
    • headaches
    • teratogenic
    • disulfiram-like reaction
    • ­cytochrome P-450
 

Please rate topic.

Average 5.0 of 1 Ratings

Thank you for rating! Please vote below and help us build the most advanced adaptive learning platform in medicine

The complexity of this topic is appropriate for?
How important is this topic for board examinations?
How important is this topic for clinical practice?
Topic COMMENTS (2)
Private Note