Updated: 3/15/2015

Flucytosine

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Introduction
  • Classification
    • antifungal
      • block pyrimidine synthesis
        • flucytosine
  • Drugs
    • flucytosine
Mechanism
  • Action
    • converted to 5-fluorouracil by fungal cytosine deaminase
      • blocks pyrimidine synthesis, inhibiting DNA synthesis
  • Resistance develops rapidly if drug is used alone
Uses
  • Used with amphotericin B
  • Cryptococcus
    • especially cryptococcal meningitis
  • Candida
    • especially candidal endocarditis
Adverse effects
  • Bone marrow toxicity
  • Nausea/vomiting
  • Diarrhea
Pharmacology
  • Good CSF penetration
 

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