Updated: 7/23/2017

Polymyxins

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Introduction
  • Classification
    • antibiotic
      • miscellaneous
        • polymyxins
  • Drugs
    • polymyxin B
    • polymyxin E
Mechanism
  • Action
    • polymyxins are polypeptides that act as detergents
      • cationic, basic
    • they break up cell membranes of Gram-negative bacteria
    • they also bind and inactivate endotoxin
Uses
  • Topical Gram-negative infections
    • usually used topically due to toxicity
    • Enterobacter
    • Pseudomonas
    • especially resistant infections
Adverse effects
  • If used systemically
    • neurotoxicity
    • acute renal tubular necrosis
 

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