Updated: 2/26/2019

[Blocked from Release] Paramyxoviruses

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Introduction
  • Paramyxoviridae include
    • parainfluenza
    • mumps
    • rubeola (measles)
    • respiratory syncytial virus (RSV)
  • All are associated with
    • lungs
      • all contain surface F (fusion) protein
        • causes respiratory epithelial cells to fuse resulting in multinucleated giant cells
        • not found in orthomyxoviridae
    • children
      • most infections occur in kids
    • viremia
      • viruses are disseminated throughout the body
  • Characteristics in common
    • RNA
      • single-stranded
        • not segmented as in orthomyxoviridae
      • negative-sense
      • linear
    • enveloped
    • helical nucleocapsid
    • contain hemagglutinin (HA) and neuraminidase (NA)
      • except RSV
      • rubeola (measles) has no NA
      • HA and NA are found in the same glycoprotein spike, unlike in orthomyxoviridae
 

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