Updated: 3/15/2015

Enterobacteriaceae

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Overview
  • A member of the enterics
  • Diverse family including
    • E. coli
    • Klebsiella
    • Salmonella
    • Shigella
    • Enterobacter
    • Serratia
    • Proteus
  • All species
    • ferment glucose
    • are oxidase negative
  • Antigens 
    • all species have somatic (O) antigen
      • somatic antigen is the polysaccharide of endotoxin
    • the capsular (K) antigen is related to the virulence of the bug
    • the flagellar (H) antigen is found in motile species
  • Think "COFFEe"
    • capsular
    • O antigen
    • flagellar antigen
    • ferment glucose
    • enterobacteriaceae
Salmonella vs. Shigella
  • Both are non-lactose fermenters
  • Both invade intestinal mucosa and can cause bloody diarrhea
  • Salmonella
    • have flagella and can disseminate hematogenously
      • "salmon swim"
    • produce H2S
    • symptoms may be prolonged with antibiotic treatments
    • typically a monocytic response
    • animal reservoir
      • except S. typhi, which is only found in humans
  • Salmonella typhi causes typhoid fever
    • fever, diarrhea, headache, rose spots on abdomen
    • can remain in gallbladder chronically
  • Shigella
    • more virulent (101 organisms) than Salmonella (105 organisms)
    • do not have flagella but can propel themselves while within a cell
      • via actin polymerization
  • Transmission
    • food
    • fingers
    • feces
    • flies
 

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