Updated: 12/18/2017

Muscarinic Antagonists

Topic
Review Topic
0
0
Pirenzepine
  • Other agents: propantheline
  • Mechanism
    • similar to the action of atropine but more selective
      • note the "-pine" suffix
    • block M1 receptors on ECL cells
      • ↓ histamine secretion
        • histamine normally acts on parietal cells to ↑ acid production
    • block M3 receptors on parietal cells
      • ↓ HCl secretion
  • Clinical use
    • peptic ulcer
      • PPI use is preferred due to less side effects
  • Toxicity
    • general antimuscarinic side effects
      • tachycardia
      • xerostomia
      • difficulty focusing eyes
Scopolamine
  • Mechanism
    • blocks M1 receptors in the vomiting center
  • Clinical use
    • motion sickness
  • Toxicity
    • sedation
    • short-term memory block
 

Please rate topic.

Average 3.0 of 1 Ratings

Thank you for rating! Please vote below and help us build the most advanced adaptive learning platform in medicine

The complexity of this topic is appropriate for?
How important is this topic for board examinations?
How important is this topic for clinical practice?
Topic COMMENTS (7)
Private Note