Updated: 10/28/2019

Other Anti-Nausea Medications

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Snapshot
  • A 30-year-old woman prepares to fly over 12 hours on a business trip. She is expected to give a very important presentation upon arrival and is nervous about her history of motion sickness with long flights. She has tried dimenhydrinate and meclizine in the past without much help. Her physician suggests trying scopolamine patches but warns her of the most common side effect of dry mouth.
Pirenzepine
  • Drugs
    • scopolamine
    • aprepitant
    • dimenhydrinate
    • meclizine
    • promethazine
Anti-Emetics

Scopolamine
Aprepitant
Anti-Histamines
Mechanism of action 
  • Muscarinic antagonist in the central nervous system
  • Substance P antagonist
  • Blocks neurokinin-1 receptors in the central nervous system
Dimenhydrinate
  • First generation anti-histamine
Meclizine
  • Anti-histamine
  • Also has mild anti-cholinergic effects
Promethazine
  • Anti-histamine
  • Also has dopamine receptor angatonism
Clinical use
  • Motion sickness
  • Anti-emetic, in the setting of chemotherapy
  • Motion sickness
  • Nausea and vomiting (promethazine)
Adverse effects
  • Dry mouth
  • Drowsiness
  • Dizziness
  • Blurry vision
  • Induces CYP3A4
  • Headache
  • Constipation
  • Drowsiness
  • Anti-cholinergic effects
  • Acute glaucoma
  • Dry mouth
  • Extrapyramidal symptoms (promethazine)
 
 

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