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Review Question - QID 215151

DNA Repair Base Excision Repair Function QID: 215151 (M1.OMB.1)
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QID 215151 (Type "215151" in App Search)
A 15-year-old boy presents to the emergency department with a 2-month history of malaise, weight loss, melena, and constipation and is found to have colon cancer after extensive workup. He has no significant past medical history but family history is significant for multiple relatives with early-onset colon cancer. The tumor is removed and biochemical analysis reveals dramatically increased levels of deaminated cytosines in the DNA content of the cells. Multiple other rare base-pair oxidations and modifications are found that are not present in normal DNA. Which of the following is most likely defective in this patient?
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