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Review Question - QID 215133

Thalassemia Anemia Evaluation Imaging QID: 215133 (M1.OMB.1)
In scope icon M 1 A
QID 215133 (Type "215133" in App Search)
A 9-year-old boy is brought to a pediatrician to establish care after his family immigrates to the United States. He has received some vaccinations previously but otherwise did not have routine medical care because his family are refugees from a resource-poor setting. His parents say that he is often tired even after light exertion and appears much paler than his siblings. They deny other symptoms such as fever, chest pain, abdominal pain, or hematuria. His parents say that a strange finding was observed on a skull radiograph years ago so repeat radiographs are obtained. The relevant results are shown in Figure A. Laboratory studies show the following:

Hemoglobin: 6.4 g/dL
Mean corpuscular volume: 68 fL
Ferritin: 25 ng/mL

Which of the following mechanisms is most likely responsible for this patient's symptoms?
  • A
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  • A