Review Question - QID 214580

A 3-year-old boy is brought to a pediatrician to establish care after his parents moved across the country. On presentation, his parents say that he is hard to control at home and can behave aggressively with other children. Physical exam reveals obesity and small testicles. He does not follow the physician's directions during developmental testing; however, he appears to be globally delayed in motor function. His parents also recall that he had some problems with feeding shortly after birth but they do not recall the cause of the issues. This patient's disease is most closely associated with which of the following principles?