Review Question - QID 214514

A 27-year-old woman presents to a geneticist for preconception counseling because of a personal and family history of early onset cancers. Specifically, she was diagnosed 3 years ago with adrenocortical carcinoma that was successfully treated with surgical resection and aggressive chemoradiation. She has been in remission for 2 years. Family history also includes breast cancer in her mother, osteosarcoma in her brother, soft tissue sarcomas in her maternal uncle, and multiple leukemias on the maternal side of the family. A defect on which of the following chromosomes is most likely responsible for this family history of cancers?