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Review Question - QID 214510

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QID 214510 (Type "214510" in App Search)
A 10-year-old boy is brought to a pediatrician for establishment of care after his family moved from another country last year. On presentation, he is found to be in the 5th percentile for both height and weight. His medical records are currently unavailable, but his parents say that he has always been one of the smallest kids in the class. Physical exam reveals a flattened back of the head, malocclusion of the teeth, and more teeth than expected. He is also found to have decreased prominence of the shoulder girdle. Which of the following gene mutations would most likely be seen in this patient?