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Review Question - QID 109831

Hemoglobin C Introduction Genetics QID: 109831 (M1.HE.17.4870)
In scope icon M 2 C
QID 109831 (Type "109831" in App Search)
A 9-year-old African-American boy presents to his primary care physician in order to be evaluated for fatigue and shortness of breath. He lives in an old house with his parents and eats a diet consisting of mostly fast food and soda. A few days prior to presentation he ate fava beans. His mom has noticed that he is tired particularly in the morning. Physical exam reveals a thin, pale boy with decreased color under his eyelids. A panel of hematologic tests is obtained with the following results:

Hemoglobin: 12 g/dL
Leukocyte count: 5,250/mm^3
Platelet count: 172,000/mm^3
Mean corpuscular volume: 95 µm^3
Direct bilirubin: Normal
Indirect bilirubin: Increased

A blood smear is obtained and shown in Figure A demonstrating internal crystals of Hemoglobin C in red blood cells. Which of the changes are associated with the most likely cause of this patient's condition?
  • A
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  • A