Review Question - QID 109408

A 25-year-old male is brought to the emergency department by his friends after a camping trip. He and his friends were in the woods camping when the patient started experiencing severe right upper quadrant abdominal pain after foraging and ingesting some wild mushrooms about 3 hours earlier. The patient is lethargic on exam and appears jaundiced. He has scleral icterus and is severely tender to palpation in the right upper quadrant. He has scattered petechiae on his extremities. Liver function tests are:

Serum:
Na+: 134 mEq/L
Cl-: 100 mEq/L
K+: 4.2 mEq/L
HCO3-: 24 mEq/L
Urea nitrogen: 50 mg/dL
Glucose: 100 mg/dL
Creatinine: 1.4 mg/dL
Alkaline phosphatase: 400 U/L
Aspartate aminotransferase (AST, GOT): 3278 U/L
Alanine aminotransferase (ALT, GPT): 3045 U/L
gamma-Glutamyltransferase (GGT): 100 U/L

The most likely cause of this patient’s clinical presentation acts by inhibiting which of the following molecules?