Review Question - QID 108789

A 62-year-old male presents to his primary care physician complaining of a chronic cough. He reports a six-month history of progressively worsening cough and occasional hemoptysis. He has lost ten pounds over the same time frame. His medical history is notable for hypertension, hyperlipidemia, and diabetes mellitus. He has a 50-pack-year smoking history. A chest radiograph reveals a coin-like central cavitary lesion. Tissue biopsy demonstrates findings consistent with squamous cell carcinoma. The patient is referred to a pulmonologist who starts the patient on a chemotherapeutic drug. However, after several weeks on the drug, the patient develops sensorineural hearing loss. Which of the following mechanisms of action is consistent with the most likely medication prescribed in this case?