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Review Question - QID 108745

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QID 108745 (Type "108745" in App Search)
A 64-year-old male presents to the emergency room with difficulty breathing. He recently returned to the USA following a trip to Singapore. He reports that he developed pleuritic chest pain, shortness of breath, and a cough. His temperature is 99°F (37.2°C), blood pressure is 140/85 mmHg, pulse is 110/min, and respirations are 24/min. A spiral CT reveals a pulmonary embolus in the right segmental pulmonary artery. Results from a complete blood count are all within normal limits. He is admitted and started on unfractionated heparin. Four days later, the patient develops unprovoked epistaxis. A complete blood count reveals the following:

Leukocyte count: 7,000/mm^3
Hemoglobin: 14 g/dl
Hematocrit: 44%
Platelet count 40,000/mm^3

What is the underlying pathogenesis of this patient’s condition?