Review Question - QID 108541

A 26-year-old female who is 12 weeks pregnant presents to her primary care physician because she is concerned about her acne. While she has struggled with acne for most of her adult life, the acne has become more severe in the past few months. She has used benzoyl peroxide, salicylic acid, and topical antibiotics in the past but these treatments have had little effect. The patient would like to try minocycline, which worked for a friend of hers. The physician responds that this drug cannot be given to pregnant women, and offers to start the patient on the drug after she delivers the baby. Minocycline may to toxic to the fetus through which mechanism?