Review Question - QID 108500

A 10-year-old boy who recently immigrated to the United States from Africa with his family is brought to the emergency department by his mother for a progressively worsening ulcerative lesion on his jaw. His mother reports that her son’s right jaw has rapidly enlarged over the past few months. He says that it is very tender though he doesn’t recall any trauma to the site. In addition, the mother says her son hasn’t been himself the past few months with intermittent fever, weakness, and fatigue. Physical exam reveals a large, ulcerating right jaw mass that is draining serous fluid and painless cervical and axillary lymphadenopathy. Laboratory results are notable for an elevated serum lactate dehydrogenase. A biopsy of the right jaw mass is shown in the photograph. Which of the following chromosomal translocations is most likely to be found in this patient’s lesion?