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Review Question - QID 108493

Crigler-Najjar Syndrome Introduction Hereditary unconjugated hyperbilirubinemia QID: 108493 (M1.GI.17.4717)
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QID 108493 (Type "108493" in App Search)
A one-week-old boy presents with yellow sclerae, severe lethargy, and decreased muscle tone. His mother notes that the symptoms started shortly after birth and have been progressively worsening. The patient is breast fed and takes no medications. His labs are within normal limits with the exception of his liver function tests as follows:

ALT: 8 U/ L
AST: 10 U/L
Alkaline phosphatase: 50 U/L
Albumin: 3.7 g/dL
Total protein: 6.7 g/dL
Bilirubin, total: 29.4 mg/dL
Bilirubin, unconjugated: 29.2 mg/dL
Bilirubin, conjugated: 0.2 mg/dL

The boy is taken immediately for treatment. What is the most likely underlying cause of his condition?
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