Review Question - QID 108467

A 20-year-old female presents to the emergency department with squeezing right upper quadrant pain worse after eating. She has a history of a microcytic, hypochromic anemia with target cells. Physical exam shows severe tenderness to palpation in the right upper quadrant and a positive Murphy's sign. By genetic analysis a single point mutation is detected in the gene of interest. Despite this seemingly minor mutation, the protein encoded by this gene is found to be missing a group of 5 consecutive amino acids though the amino acids on either side of this sequence are preserved. This point mutation is most likely located in which of the following regions of the affected gene?