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Notochord
0%
0/261
Endoderm
1/261
Neural crest cells
79%
207/261
Mesoderm
2%
5/261
Ectoderm
18%
46/261
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This patient's lesion is most consistent with melanoma, which is derived from melanocytes. Melanocytes are of neural crest cell origin. Neural crest cells migrate and transform into a number of different tissue types during normal embryologic development. These cellular fates include bones of the craniofacial skeleton, nervous tissue, and melanocytes. Melanoma results from malignant transformation of melanocytes. Melanoma remains a difficult-to-treat malignancy due to both its predilection to remain dormant as well as its tendency to metastasize to almost anywhere in the body. Figure A is a photograph of a patient with a melanoma of the right cheek. Incorrect Answers: Answer 1: The notochord is an embryologic structure that is important for paracrine signaling and cell differentiation. It becomes the nucleus pulposus in the fetus. Answer 2: The endoderm becomes the gastrointestinal tract. Answer 4: The mesoderm becomes connective tissue, including smooth and striated muscle fibers. Answer 5: The ectoderm becomes the epidermis and nervous system.
3.9
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