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Mechanism
  • cGMP phosphodiesterase inhibitor
    • results in less cGMP degradation and ↑ cGMP 
  • Drives smooth muscle relaxation in the corpus cavernosum
    • ↑ blood flow to penis

Indications
  • Erectile dysfunction
  • Pulmonary hypertension
Toxicity
  • Side effects
    • headache
    • flushing
    • dyspepsia
    • impaired blue-green color vision
  • Do not co-administer with nitrates
    • risk of life-threatening hypotension
 

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