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Overview
  • Drug reactions organized by system
    • cardiovascular
    • GI
    • hematologic 
    • musculoskeletal
    • neurologic
    • renal
    • reproductive/endocrine
    • respiratory
    • multiorgan
Medication Reactions
 
Reaction
Causal Agent
Cardiovascular
Atropine-like side effects
  • TCAs
Coronary vasospasm
  • Cocaine
  • Sumatriptan
Cutaneous flushing
  • Vancomycin
  • Adenosine
  • Niacin (reduced by co-administration of aspirin)
  • Calcium channel blockers
Dilated cardiomyopathy
  • Doxorubicin (Adriamycin) 
  • Daunorubicin
  • Cocaine
Torsades de pointes
  • Class IA antiarrhythmic (disopyramide, quinidine, procainamide)
  • Class III  antiarrhythmics (amiodarone, sotalol)
  • Lithium
  • Chloroquine
  • Erythromycin, clarithromycin
  • Haloperidol, thioridazine, ziprasidone
GI
Acute cholestatic hepatitis
  • Macrolides
  • Troglitazone
Focal to massive hepatic necrosis
  • Halothane
  • Valproic acid
  • Acetaminophen
  • Amanita phalloides
  • Carbon tetrachloride
Hepatitis
  • INH
  • Phenytoin
  • Methyldopa
Pseudomembranous colitis
  • Clindamycin
  • Ampicillin
  Hematologic
 Agranulocytosis  
  • Clozapine
  • Carbamazepine
  • Colchicine
  • Propylthiouracil
  • Methimazole
  • Dapsone
  • Cephalosporins
Aplastic anemia
  • Chloramphenicol
  • Benzene
  • NSAIDs
  • Propylthiouracil
  • Methimazole
  • Carbamazepine
  • Phenytoin
Direct Coombs-positive hemolytic anemia
  • Methyldopa
  • Penicillin
Gray baby syndrome
  • Chloramphenicol
Hemolysis in G6PD-deficient patients
  • Isoniazid (INH)
  • Dapsone
  • Sulfonamides
  • Primaquine
  • Chloroquine
  • Aspirin
  • Ibuprofen
  • Nitrofurantoin
  • Methylene blue
Megaloblastic anemia
  • Phenytoin
  • Methotrexate
  • Sulfonamides
  • 6-mercaptopurine
  • Cytosine arabinoside
Thrombotic complications
  • Contraceptives
Musculoskeletal
Gingival hyperplasia
  • Phenytoin
  • Cyclosporin
  • Nifedipine
Gout
  • Furosemide
  • Thiazides
  • Cyclosporin
  • Levodopa
  • Niacin
Osteoporosis
  • Corticosteroids
  • Heparin
  • Proton pump inhibitors
  • Lithium
Photosensitivity
  • Sulfonamides
  • Amiodarone
  • Tetracycline
  • Fluoroquinolones
Rash (Stevens-Johnson syndrome)
  • Ethosuximide
  • Lamotrigine
  • Carbamazepine
  • Phenobarbital
  • Phenytoin
  • Sulfonamides
  • Fluorquinolones
  • Furosemide
  • Penicillin
  • Allopurinol
Rhabdomyolysis
  • Statins
SLE-like syndrome
  • Hydralazine
  • INH
  • Procainamide
  • Phenytoin
  • Carbamazepine
Tendonitis, tendon rupture, and cartilage damage in children
  • Fluoroquinolones 
Neurologic
Cinchonism 
  • Quinidine
  • Quinine
Diabetes insipidus
  • Lithium
  • Demeclocycline
Parkinson-like syndrome
  • Haloperidol
  • Chlorpromazine
  • Reserpine
  • Metoclopramide
  • MPTP (causes permanent Parkinson's)
  • Clozapine
  • Prochlorperazine
  • Cinnarizine
Seizures
  • Bupropion
  • Venlafazine
  • Tramadol
  • Diphenhydramine
  • Imipenem/cilastatin
  • Isoniazid
Tardive dyskinesia
  • Antipsychotics (chlorpromazine)
Renal/GU
Fanconi's syndrome
  • Expired tetracycline
  • Tenofovir
Interstitial nephritis
  • Methicillin
  • NSAIDs
  • Acetominophen
  • Furosemide
  • Allopurinol
Hemorrhagic cystitis
  • Cyclophosphamide
  • Ifosfamide (prevented by mesna administration)
Reproductive/Endocrine
Adrenocortical insufficiency
  • Withdrawal of glucocorticoid therapy
Gynecomastia
  • Spironolactone
  • Digitalis
  • Cimetidine
  • Clomiphene
  • Busulfan, nitrourea, vincristine (direct testicular injury)
  • Chronic alcohol use
  • Estrogens
  • Ketoconazole
  • Finasteride
Hot Flashes
  • Tamoxifen
  • Clomiphene
Hypothyroidism
  • Lithium
  • Amiodarone
  • Neck radiation therapy
Respiratory
Cough
  • ACE inhibitors
Pulmonary fibrosis
  • Bleomycin
  • Amiodarone
  • Busulfan
  • Methotrexate
  • Cyclophosphamide
  • Hydralazine
  • Tocainide
  Multiorgan
Disulfiram-like reaction
  • Sulfonylurea
  • Metronidazole
Nephrotoxicity/neurotoxicity
  • Polymyxins
Nephrotoxicity/ototoxicity
  • Aminoglycosides (neomycin)
  • Vancomycin
  • Loop diuretics (ethacrynate, furosemide, bumetanide)
  • Cisplatin
  • Mercuric chloride

 

 

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